pentobarbital will reduce the level or impact of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Pitolisant exposure is lessened by fifty% if coadministered with potent CYP3A4 inducers.pentobarbital will decrease the level or result of ixabepilone by affecting hepatic/intestinal enzyme CYP3A4